Our Research

Cellular senescence is a complex process, that occur in response to many stressors, including mutations on proto-oncogenes, telomere shortening, and DNA damage. Understanding the mechanisms that drive replicating cells to become senescent, in other words, halt their cell cycle and enter a state of permanent cell cycle arrest, is key to understand the process of aging, and the development of aging associated diseases, such as neurodegenerative diseases (including Alzheimer's disease (AD) and Parkinson's disease (PD)), cancer, insulin resistance and nonalcoholic fatty liver disease (NAFLD). In our lab, we combine molecular biology, biochemistry and analytical chemistry strategies to study the mechanisms of senescence and its associated illnesses in a multi-omics approach.

Selected Publications

Panda P, Ferreira CR, Cooper BR, Schaser AJ, Aryal UK (2025) Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. J Proteome Res [J Proteome Res]

Mohallem R, Schaser AJ, Aryal UK (2024) Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain. Mol Cell Proteomics 23 [Mol Cell Proteomics]

Mohallem, R., and Aryal, U. K. (2024) Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mol Cell Proteomics 23, 100715 [Mol Cell Proteomics]

Kim, S. Q., et al. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communications. [BBRC]

Kim, S. Q., et al. (2022). Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. Cells 11(7): 1172. [Cells]

Mohallem, R. & Aryal, U. K. Quantitative Proteomics and Phosphoproteomics Reveal TNF-α-Mediated Protein Functions in Hepatocytes. Molecules 26, 5472 (2021). [Molecules]

Mohallem, R. & Aryal, U. K. Regulators of TNFα mediated insulin resistance elucidated by quantitative proteomics. Scientific Reports 10, 20878 (2020). [Scientific Reports]