The Aryal Laboratory
Overview
The Aryal lab specializes in Mass Spectrometry based approaches to investigate the underlying mechanisms of senescence and aging, at both the cellular and organism levels. Our lab is interested in understanding how the changes in the the proteome, as well as the dynamic changes in protein post-translational modifications, contribute to aging and aging associated diseases, such as Cancer and Neurodegenerative diseases
Recent Publications
Punyatoya Panda, Christina R. Ferreira, Allison J. Schaser, Uma K. Aryal; Integrated Hepatic Lipidome Analysis in Aging Mice. J. Proteome Res. 2026
Punyatoya Panda, Rodrigo Mohallem, Rita de Kassia Rodrigues Bezerra Filgueira, Niwako Ogata, Uma K. Aryal; Urine and Serum Proteome and Lipidome Analysis of Naturally Aging Feline Species. J. Proteome Res. 2026
Rodrigo Mohallem, Deepika Dhawan, Alexander W. Enstrom, Deborah W. Knapp, Uma K. Aryal; Proteomic Signatures of Vemurafenib Resistance in Canine Urothelial Carcinoma Harboring the BRAFV595E Mutation. J. Proteome Res. 7 August 2026; 25 (8): 4262–4275.
Panda, P., Giri, S.J., Sherman LA, Kihara D, Aryal UK (2025) et al. Proteomic analysis of metabolic adaptation in a unicellular cyanobacterium during light-dark cycles and nitrogen fixation. Sci Rep15, 35561 [ Scientific Reports]
Mohallem, Rodrigo, Allison J. Schaser, and Uma K. Aryal. "Proteomic and phosphoproteomic signatures of aging mouse liver." GeroScience (2025): 1-20. [GeroScience]
Panda P, Giri SJ, Sherman LA, Kihara D, Aryal UK (2025) Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth. J Proteome Res 24: 419-432 [J Proteome Res]
Panda P, Ferreira CR, Cooper BR, Schaser AJ, Aryal UK (2025) Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.J Proteome Res [J Proteome Res]
Mohallem, R, Schaser, AJ, Aryal, U.K. (2024) Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain. Mol Cell Proteomics 23 [Mol Cell Proteomics]
Mohallem, R., and Aryal, U. K. (2024) Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mol Cell Proteomics 23, 100715 [Mol Cell Proteomics]
Kim, S. Q., et al. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communications. [BBRC]
Kim, S. Q., et al. (2022). Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. Cells 11(7): 1172. [Cells]
Mohallem, R., and Aryal, U.K. (2021). Quantitative Proteomics and Phosphoproteomics Reveal TNF-α-Mediated Protein Functions in Hepatocytes. Molecules 26, 5472. [Molecules]
News
Dr. Aryal presented an invited talk, "Proteomics Signature of Health and Aging” at the 2026 American Society of Animal Sciences meeting, held July 19-23, 2026, in Madison, Wisconsin.
The Aryal laboratory receives NIH R01 funding through a collaborative project involving Purdue University and the University of Buffalo. Dr. Aryal serves as a sub-contract PI for Oklahoma State University.
The Aryal Lab invites applications for a fully funded Postdoctoral Research Fellow. For more details visit: https://jobs.okstate.edu/jobs/postdoctoral-position-in-proteomics-and-parkinson-s-research-bf9461-stillwater-oklahoma-united-states
Graduate student Israt Mishu won the 2nd prize for the graduate poster presentation in Microbiology and Molecular Genetics Symposium at Oklahoma State University!
Graduate student Binayok Sharma received the Jackson Family Endowment Award in recognition of outstanding achievement in the Department of Biochemistry and Molecular Biology.
Graduate student Punyatoya Panda successfully defended her PhD Dissertation! Congrats!
Dr. Aryal was the featured expert at OSU Research on Tap on March 16th at the Student Union - Atherton Hotel, The State Room Piano Lounge. He spoke on “From Milk to Aging: What Proteins Teach Us About Health,” highlighting the role of proteomics and mass spectrometry technologies in advancing nutrition and milk research. Watch full video→Learn more about the event →
Dr. Aryal and Punya attended the 2026 ASBMB Annual Meeting in Washington, D.C., where they presented research from the Aryal Lab. Punya delivered a flash talk titled “Spatial Lipid Imaging of the Aging Brain Using Mass Spectrometry” sharing new insights into how advanced imaging can reveal the complex chemistry of brain aging.
The Aryal Lab moved to Oklahoma State Univerity!
Graduate Student Punyatoya Panda completed her preliminary exam! Congrats!
Graduate Student Rodrigo Mohallem successfully defended his PhD Dissertation! Congrats!
Our lab attended and presented our work at the 2025 ASBMB conference in Chicago!
Dr. Aryal presented his lab’s work at the Waters Imaging Innovation submit on April 1, 2025
Our lab attended and presented our work at the 2025 Indiana Academy of Sciences conference! Rodrigo presented at the Emerging Scientist Research Oral Competition and Punyatoya presented at the Section Oral Presentations. Aryaman and Malyka presented at the poster session. Rodrigo won 1st place at the oral competition, and Aryaman won 2nd place at the poster competition!
Dr. Aryal’s research accomplishments were highlighted on the February PVM news issue!
Research accomplishments of CPB’s Uma Aryal featured in ASBMB Today Article
Our lab attended and presented our work at the 2025 US-HUPO conference in Philadelphia!
Our research was featured as an article on the January ASBMB TODAY issue! Check it out here: A proteomic hunt for phosphosites in the aging brain
Our research was featured as an article on the December Obesity, Fitness & Wellness Week issue! Check it out here: Studies from Purdue University Yield New Data on Neurodegenerative Diseases and Conditions
Our research was featured as an article on the November AAAS and EurekAlert! issue! Check it out here: Unlocking the Mysteries of the Brain