The Aryal Laboratory

Overview

The Aryal lab specializes in Mass Spectrometry based approaches to investigate the underlying mechanisms of senescence and aging, at both the cellular and organism levels. Our lab is interested in understanding how the changes in the the proteome, as well as the dynamic changes in protein post-translational modifications, contribute to aging and aging associated diseases, such as Cancer, Neurodegenerative diseases, Insulin Resistance and Nonalcoholic Fatty Liver Disease (NAFLD)

Recent Publications

Mohallem, R., and Aryal, U. K. (2024) Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mol Cell Proteomics 23, 100715 [Mol Cell Proteomics]

Kim, S. Q., et al. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communications. [BBRC]

Kim, S. Q., et al. (2022). Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. Cells 11(7): 1172. [Cells]

Mohallem, R., and Aryal, U.K. (2021). Quantitative Proteomics and Phosphoproteomics Reveal TNF-α-Mediated Protein Functions in Hepatocytes. Molecules 26, 5472. [Molecules]

Mohallem, R. and U. K. Aryal (2020). Regulators of TNFα mediated insulin resistance elucidated by quantitative proteomics. Scientific Reports 10(1): 20878. [Scientific Reports]

News

  • Undergraduate Student Aryaman Dewan was awarded the 2025 Promega D.O.O.R.S Scholarship Award!

  • Graduate Student Rodrigo Mohallem received the 2025 Bilsland Dissertation Fellowship Award!

  • Dr. Uma Aryal received the 2024 Zoetis Award for Outstanding Achievement and Dedication in the Field of Veterinary Medicine!

  • Graduate Student Punyatoya Panda received the 2024 CTSI Kroenke Poster Award!

  • Graduate Student Rodrigo Mohallem received the 2024 PVM research day Best Poster Award, 1st Place!

  • Our research was featured as an article on the July PVM news issue! Check it out here: Demystifying the Aging Process – Study Sheds New Light on Age-related Diseases

  • Graduate Student Rodrigo Mohallem received the 2023 PVM Graduate Student Award, 2nd Place!