The Aryal Laboratory
Overview
The Aryal lab specializes in Mass Spectrometry based approaches to investigate the underlying mechanisms of senescence and aging, at both the cellular and organism levels. Our lab is interested in understanding how the changes in the the proteome, as well as the dynamic changes in protein post-translational modifications, contribute to aging and aging associated diseases, such as Cancer and Neurodegenerative diseases
Recent Publications
Panda P, Ferreira CR, Cooper BR, Schaser AJ, Aryal UK (2025) Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. J Proteome Res [J Proteome Res]
Mohallem, R, Schaser, AJ, Aryal, U.K. (2024) Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain. Mol Cell Proteomics 23 [Mol Cell Proteomics]
Mohallem, R., and Aryal, U. K. (2024) Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mol Cell Proteomics 23, 100715 [Mol Cell Proteomics]
Kim, S. Q., et al. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communications. [BBRC]
Kim, S. Q., et al. (2022). Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. Cells 11(7): 1172. [Cells]
Mohallem, R., and Aryal, U.K. (2021). Quantitative Proteomics and Phosphoproteomics Reveal TNF-α-Mediated Protein Functions in Hepatocytes. Molecules 26, 5472. [Molecules]
News
Dr. Aryal’s research accomplishments were highlighted on the February PVM news issue!
Research accomplishments of CPB’s Uma Aryal featured in ASBMB Today Article
Our lab attended and presented our work at the 2025 US-HUPO conference in Philadelphia!
Our research was featured as an article on the January ASBMB TODAY issue! Check it out here: A proteomic hunt for phosphosites in the aging brain
Our research was featured as an article on the December Obesity, Fitness & Wellness Week issue! Check it out here: Studies from Purdue University Yield New Data on Neurodegenerative Diseases and Conditions
Our research was featured as an article on the November AAAS and EurekAlert! issue! Check it out here: Unlocking the Mysteries of the Brain
Our research was featured as an article on the November PVM news issue! Check it out here: Unlocking the Mysteries of the Brain
Undergraduate Student Aryaman Dewan was awarded the 2025 Promega D.O.O.R.S Scholarship Award!